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Synthesis 2018; 50(11): 2191-2199
DOI: 10.1055/s-0036-1591557
DOI: 10.1055/s-0036-1591557
paper
CuI/Et2NH-Catalyzed One-Pot Highly Efficient Synthesis of 1,4-Disubstituted 1,2,3-Triazoles in Green Solvent Glycerol
This research was supported by College of Chemistry and Chemical Engineering, Henan University, and Institute of Chemistry Co. Ltd., Henan Academy of Sciences.Further Information
Publication History
Received: 04 January 2018
Accepted after revision: 27 February 2018
Publication Date:
28 March 2018 (online)
Abstract
A concise one-pot three-component reaction of organic halides, terminal acetylenes, and sodium azide provided an efficient route for the synthesis of 1,2,3-triazoles. A variety of 1,2,3-triazoles were prepared in good to excellent yields with green solvent glycerol. This procedure used CuI and diethylamine, which are two easily available reagents as the new catalytic system at room temperature.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591557.
- Supporting Information
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